20 - Imaging of craving in medication Arch Gen Psychiatry....

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7/1/10 Imaging of craving in medication testing Arch Gen Psychiatry. 2008 Apr;65(4):466-75. Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people. Myrick H, Anton RF, Li X, Henderson S, Randall PK, Voronin K. CONTEXT: Medication for the treatment of alcoholism is currently not particularly robust. Neuroimaging techniques might predict which medications could be useful in the treatment of alcohol dependence. OBJECTIVE: To explore the effect of naltrexone, ondansetron hydrochloride, or the combination of these medications on cue-induced craving and ventral striatum activation. DESIGN: Functional brain imaging was conducted during alcohol cue presentation. SETTING: Participants were recruited from the general community following media advertisement. Experimental procedures were performed in the magnetic resonance imaging suite of a major training hospital and medical research institute. PATIENTS: Ninety non-treatment-seeking alcohol-dependent (by DSM-IV
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20 - Imaging of craving in medication Arch Gen Psychiatry....

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