24 - 7/1/10 Liver-related Deaths France USSR Germany Great...

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Unformatted text preview: 7/1/10 Liver-related Deaths France USSR Germany Great Britain Australi a Canada USA Japan Mexico 7/1/10 Alcohol Consumption Alcoholic Liver Disease EtOH Normal 3rd "hit" Steatosis 2nd "hit" (TNF? ) Steatohepatiti Cirrhosis s 7/1/10 Steatosis (Fatty Liver) Common Reversible Few symptoms Hepatomegaly Slightly liver enzymes 7/1/10 (Fat + inflammation & injury) Less common Precursor of cirrhosis * Generally few symptoms Can multi-organ failure, death Steatohepatitis * Can also occur in patients with cirrhosis 7/1/10 Cirrhosis Scar, nodules Eventually develops in 20% Morbidity common (jaundice, ascites, bleeding, cachexia, infections, encephalopathy) 7/1/10 Liver cancer, death in most within 10 years Therapy Patients Animals Abstinence Y(incomplete) Y Nutrition Y/N ?? Antibiotics ?? Y Anti-TNF ??(steroids) Y Anti-oxidants Maybe Y Rx Efficacy 7/1/10 7/1/10 The human gut contains an abundant bacterial flora. The inset shows a scanning electron micrograph of part of the small intestine, with bacteria shown in green. (Bajzer and Seeley) ...
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24 - 7/1/10 Liver-related Deaths France USSR Germany Great...

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