29 - nervous system. 7/1/10 FIGURE 4.26 Schematic...

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7/1/10 Opioid peptide gene families Three different gene families Proopiomelanocortin (POMC) Proenkephalin Prodynorphin (‘proenkephalin B’) Proopiomelanocortin Proenkephalin Prodynorphin Signal NH2 Signal NH2 Signal NH2 g-MSH α -MSH β -LPH CLIP β -MSH β -Endorphin ACTH COOH (Arg6– Gly7– Leu8) 5 6 7 1 2 3 4 COOH α -Neoendorphin Dyn A Dyn B β -Neoendorphin COOH Met-enk (Arg6– Phe7) Met-enk 12.
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7/1/10 Opioid receptors Subtype Preferred Ligand Mu (µ) Delta ( δ ) Enkephalins Kappa ( κ ) Ketocyclazocine & dynorphins **Activation of κ has much different effects than activation of µ δ.
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7/1/10 FIGURE 4.26 Schem at ic represent ation of , , and 1 μ δ κ receptor mRNA expression and binding in the rat central
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Unformatted text preview: nervous system. 7/1/10 FIGURE 4.26 Schematic representation of , , and 1 receptor mRNA expression and binding in the rat central nervous system. 7/1/10 FIGURE 4.26 Schematic representation of , , and 1 receptor mRNA expression and binding in the rat central nervous system. 7/1/10 FIGURE 4.27 (A) Determination of the extracellular levels of enkephalin in the nucleus accumbens of rats chronically treated with saline or morphine to induce a positive place conditioning. (B) Conditioned place preference induced by morphine (5 mg/kg, i.p.)....
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas at Austin.

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29 - nervous system. 7/1/10 FIGURE 4.26 Schematic...

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