30 - FIGURE 4.28 Molecular mechanisms of neuroadaptation-...

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7/1/10 FIGURE 4.28 Molecular mechanisms of neuroadaptation— opioids.
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7/1/10 One signaling cascade of metabotropic receptors: stimulation or inhibition of PKA Opioid receptors inhibit cAMP production (What are other signaling cascades used by these receptors?) opioi d u
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7/1/10 Activation of GIRK by metabotropic receptors via beta-gamma subunits
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7/1/10 Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs. Mark von Zastrow, Adena Svingos, Helena Haberstock-Debic and Chris Evans Opiate drugs such as morphine and heroin are among the most effective analgesics known. Prolonged or repeated administration of opiates produces adaptive changes in the nervous system that lead to reduced drug potency or efficacy (tolerance), as well as physiological withdrawal symptoms and behavioral manifestations such as craving when drug use is terminated (dependence). These adaptations limit the therapeutic utility of opiate drugs, particularly in the treatment of chronically painful conditions, and are thought to
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas at Austin.

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30 - FIGURE 4.28 Molecular mechanisms of neuroadaptation-...

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