31 - 7/2/10 Von Zastrow et al., Current Opinion in...

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7/2/10 Von Zastrow et al., Current Opinion in Neurobiology, 2003
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7/2/10 FIGURE 4.29 Upregulation of the cyclic adenosine monophosphate (cAMP) pathway as a mechanism of opioid tolerance and
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7/2/10 FIGURE 4.30 Whether a user is tolerant to a drug or, conversely, sensitized to it, depends in part on the levels of active cyclic adenosine monophosphate response-element binding protein (CREB) and FosB in nucleus accumbens cells. Δ
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7/2/10 MOR Knockouts Morphine has affinity for all opioid receptor subtypes (much stronger for mu) Evidence for site of action from pharmacological experiments with drugs that may act at multiple sites
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7/2/10 MOR Knockouts (MOR -/-) Morphine effect Spinal analgesia Abolished Supraspinal analgesia Abolished Reward Abolished Withdrawal Abolished Respiratory depressionAbolished Inhibition GI motilityAbolished Psychoactivating effect Abolished
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7/2/10 Vol. 293, Issue 3, 1002-1008, June 2000 µ-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol 1 ,2 Amanda J. Roberts, Jeffrey S. McDonald, Charles J. Heyser3, Brigitte L. Kieffer4, Hans W.
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31 - 7/2/10 Von Zastrow et al., Current Opinion in...

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