35 - Actions of cocaine Cocaine and amphetamine have...

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Unformatted text preview: Actions of cocaine Cocaine and amphetamine have different actions on monoamine transporters Cocaine Blocks transporter q prevents q requires 7/1/10 DA DA tra n s p o rte r A m p h e ta m in e reuptake calcium DA C o c a in e 8.1 Cocaine blocks DAT 7/1/10 Nigrostriatal DA system Psychostimulant-induced stereotyped behavior C u ae a d t p t mn ua e u sa ta A 8 S b t ni ng a i r A p r 9 as c ma t o p ca q lesions q local N ce s u l u a c me s c u b n M da e i l f r b an oe r i b n l u de injections C u ae a dt p t mn ua e A0 1 N ce s u l u a c me s c u b n Oa t r l co y f t b r ue u ec l V nr l t g e t l e t a e m na ae r a 7/1/10 Mesolimbic DA system Locomotor hyperactivity and reward q lesions q local Cu ae a dt pt m u a e n u sa t i A 8 Sbt na n r i a g A pr 9 as c ma t o p ca Nc u ul es a c me s c u bn M i l e a d f r ba oe r i n bnl ud e Cocaine into N. Accumbens ** injections Locomotor * Cu a a dt e pt m u a e n A0 1 Nc u ul es a c me s c u bn Oa t r l c f oy t br u u ec l e Vn a t g e t l et l em a r n ae r a activity * 7/1/10 13.19 Saline 10 30 Dose (mg) 100 DA sub-systems Mesolimbic projections q from VTA > nucleus accumbens q locomotor activity and reward Nigrostriatal projections q substantia 7/1/10 nigra > caudate-putamen q stereotyped motor patterns Role of DA Evidence that DA mediates the psychomotor stimulant and rewarding effects of psychostimulants q q q q q Pharmacological studies Lesion studies Neurochemical studies Correlational studies Molecular biology studies 7/1/10 ...
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas.

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35 - Actions of cocaine Cocaine and amphetamine have...

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