35 - Actions of cocaine Cocaine and amphetamine have...

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7/1/10 Actions of cocaine Cocaine and amphetamine have different actions on monoamine transporters Cocaine Blocks transporter prevents reuptake requires calcium D A t r a n s p o r t e r C o c a i n e D A D A A m p h e t a m i n e 8.1
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7/1/10 Cocaine blocks DAT
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7/1/10 Nigrostriatal DA system Psychostimulant-induced stereotyped behavior lesions local injections Nucleus accumbens Medial forebrain bundle Substantia nigra pars compacta Caudate- putamen A8 A9 Nucleus accumbens A10 Ventral tegmental area Caudate- putamen O lfactory tubercule
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7/1/10 Mesolimbic DA system Locomotor hyperactivity and reward lesions local injections Saline 10 30 100 Dose (mg) ** * * Locomotor activity Cocaine into N. Accumbens 13.19 Nucleus accumbens
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