38 - 302 Identified neurons Wiring diagram 8,000 synapses...

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Click to edit Master subtitle style 7/1/10 Genetic strategy to find in vivo targets of ethanol
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7/1/10 The search for ethanol targets underlying intoxication K+ e.g. GABA, NMDA ligand-gated channels ion channels transporters 2nd messengers EtOH PKC EtOH NT membrane fluidity In vitro In vivo Sober Intoxicated ? Ca++
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7/1/10 Natural variation in level of ethanol responses High Level Response Low Level Response Susceptibility to alcoholism Susceptibility to alcoholism and susceptibility to alcoholism
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7/1/10 C. elegans is ideal system to study neurogenetic basis for behavior Chase et al. 2004 Nat Neurosci
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Unformatted text preview: 302 Identified neurons Wiring diagram 8,000 synapses From Chen, Hall & Chklovskii From Chase et al. 2006 Measure : electrophysiology, calcium imaging Manipulate : ChR2, NpHR Genetics : free mutants, easy transgenics, RNAi by feeding, hermaphrodite reproduction Robust : freezing, explosion 7/1/10 Obj10 Average rate of locomotion and egg laying (% of untreated) Exogenous ethanol concentration (mM) Effects of ethanol on wild-type locomotion and egg laying Internal ethanol concentration (mM) 22 0.8 29 0.5...
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas at Austin.

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38 - 302 Identified neurons Wiring diagram 8,000 synapses...

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