41 - Some inhaled solvents fuels and anaesthetics do differ...

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7/1/10 A number of pharmacological and behavioural properties are common to many inhalants (eg, TCE, Tol) and other CNS depressant agents such as BZDs and barbiturates. 1. Psychomotor impairment 2. Anticonvulsant properties 3. Enhancement by EtOH 4. Biphasic effects on locomotor activity 5. Anti-anxiety effects 6. Cross-dependence with ethanol 7. Ethanol- or barbiturate-like discriminitive stimulus effects 8. Reinforcing effects. This pharmacological profile is also observed when subanaesthetic concentrations of clinically-used volatile anaesthetics are used.
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7/1/10 Chemical structures of anesthetics and inhaled solvents Obj10 Obj101 Obj102 Obj103 Obj104 Obj105 Obj106
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7/1/10 I thought all these compounds acted non-specifically by fluidizing lipids and disordering membranes. .. The common profile of effects produced by abused inhalants and alcohol and volatile anaesthetics suggests that they may have a common mechanism of action. What is that mechanism of action?
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Unformatted text preview: 7/1/10 Some inhaled solvents, fuels and anaesthetics do differ in their pharmacological profiles. This is best exemplified by the contrasting effects of diethyl ether and fluorothyl. Diethyl ether has the typical depressant & anaesthetic effects expected of this class of compounds. Fluorothyl (fluoro-ethyl ether), however, is a convulsant vapour. This suggests that the actions of these compounds depend on their chemical structures and not just their physical properties (i.e., lipophilicities). 7/1/10 Mechanisms of action of inhaled drugs of abuse. Inhibition of NMDA receptor function. NMDA receptors composed of the NR1 + NR2B subunits appear to be particularly sensitive to inhibition by a variety of inhalants including toluene, benzene, ethylbenzene, propylbenzene, TCE and nitrous oxide. AMPA receptors composed of R1 or R1+R2 subunits, or R6 kainate receptors are largely resistant to toluene....
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas.

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41 - Some inhaled solvents fuels and anaesthetics do differ...

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