42 - General CNS depression Low-dose locomotor activation...

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7/1/10 General CNS depression Low-dose locomotor activation Anticonvulsant effects Dizziness Euphoria Motor impairment Altered sensorium and behaviour. Tolerance Dependence A number of studies have demonstrated the reinforcing effects of inhalants in animals. Others have noticed similarities in the biological actions of inhalants with those of classical CNS depressants. CNS effects of inhaled agents:
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7/1/10 Classification of abused inhalants 1. Volatile alkyl nitrites (eg. amyl nitrite). Used initially for the treatment of angina, abuse began in the 1960s when ampules were ‘popped’ open for recreational use. To avoid prosecution for illegal commerce in pharmaceuticals, some companies began marketing alkyl nitrites in the form of liquid incense or aromas. The vasodilatory and smooth muscle relaxant effects of nitrites (due to release of nitric oxide) appear to form the basis for the feelings of warmth, syncope and throbbing sensations that follow their use. These compounds produced desirable experiences in
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas at Austin.

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42 - General CNS depression Low-dose locomotor activation...

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