5 - channel mimic the behavioral effects of ethanol...

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7/1/10 ETHANOL SLO-1 Activation Further Reduction in Transmitter Release K + Ca+ + Ca++ channel Model for the effects of ethanol on neuronal function Locomotion & Egg Laying
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7/1/10 Sober Intoxicated BK channel as the central mediator of ethanol intoxication in C. elegans ETHANOL e.g. GABA, NMDA ligand-gated channels BK channel transporters 2nd messengers EtOH PKC EtOH EtOH EtOH NT membrane fluidity EtOH Ca++ Locomotion & Egg Laying EtOH
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7/1/10 Can gain-of-function mutations in the SLO-1
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Unformatted text preview: channel mimic the behavioral effects of ethanol? Selective Activation by mutation slo-1(gf) ? Locomotion & Egg Laying e.g. GABA, NMDA ligand-gated channels BK channel transporters 2nd messengers PKC EtOH NT Ca++ 7/1/10 Wild type slo-1(ky389) slo-1(ky399) Gain of function mutations in the SLO-1 channel increase the magnitude of outward current Wild-type slo-1(gf)...
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