8 - Goals/Hypothesis: Ethanol Anxiolysis Understanding the...

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Unformatted text preview: Goals/Hypothesis: Ethanol Anxiolysis Understanding the molecular basis for anxiolytic effects of ethanol could have implications for the mechanisms of addiction and recidivism. A combined behavioral and expression genetic analysis can identify candidate genes influencing ethanol-induced anxiolysis and reveal novel targets for the treatment of anxiety- or ethanol-related disorders. 7/1/10 Light-dark Transition Protocol Ethanol Treatment 0 hr Restraint 15 min Injection 20 min Place mouse in light zone Begin 10 minute test session once mouse enters dark zone Ethanol or Saline Results typically expressed as % distance traveled (DTL) and % time spent in the light (TSL). 7/1/10 7/1/10 Anxiolysis-like response to acute ethanol across BXD panel 7/1/10 p < 0.05 Anxiety-like Behavior Interval Maps p < 0.63 7/1/10 Factor Analysis of Light-dark Box Phenotypes Anxiety Phenotypes Locomotor Phenotypes 7/1/10 ...
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This note was uploaded on 06/30/2010 for the course NEU 385 taught by Professor Staff during the Spring '10 term at University of Texas.

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8 - Goals/Hypothesis: Ethanol Anxiolysis Understanding the...

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