Bio final '07

Bio final '07 - Biology 195Z 12/11/07 FINAL EXAM Please...

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Biology 195Z – 12/11/07 FINAL EXAM Please fill in your PURDUE ID NUMBER on the scantron sheet. Exams without a Purdue ID number will not be graded. Please turn in your exam and scantron sheet when you are done. This exam is worth 210 points – 200 points plus 10 extra credit points. Please READ THE QUESTIONS CAREFULLY. Good luck! 1. (For questions 1 – 8) Phenylketonuria (PKU) is a genetic disease in which homozygous recessive individuals are not able to metabolize the amino acid phenylalanine. Humans have two alleles for the ability to metabolize the amino acid phenylalanine. H codes for the amino acid phenylalanine hydroxylase that digests the amino acid while h produces a defective enzyme that does not break down of phenylalanine. If individuals with PKU consume foods containing phenylalanine, mental retardation will result from the build-up of harmful molecules. In the US population the frequency of M allele is 0.99 and the frequency of m allele is 0.01. What is the expected (Hardy-Weinberg) frequency of individuals affected with PKU in the US population? (0.99 x 0.01 = 0.0099; 0.99 x 0.99 = 0.98; 0.01 x 0.01 = 0.0001; 2 x 0.99 x 0.01 = 0.0198; 2 x 0.98 x 0.0001 = 0.000196) a. 0.0099 b. 0.98 c. 0.0001 d. 0.0198 e. 0.000196 2. If another population outside the US was sampled and the frequency of heterozygotes was found to be 0.05 and the frequency of homozygous recessives was 0.002, what can you can conclude about this population relative to the US population? a. they are at Hardy-Weinberg equilibrium b. they are not at Hardy-Weinberg equilibrium c. they have evolved d. both a and c. e. both b and c. 3. The enzyme phenylalanine hydroxylase consists of four subunits. The enzyme is an example of what level of protein structure? a. quinternary b. quaternary c. tertiary d. secondary e. primary 4. The enzyme phehylalanine hydroxylase is composed of a. lipids b. carbohydrates c. amino acids d. nucleic acids e. finalic acids
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5. The defective phenylalanine hydroxylase is made through a. transduction b. translation d. transcription d. reverse transcription e. replication 6. At which of the following would a phenylalanine hydroxylase subunit be produced? a. nuclear membrane b. ribosome c. smooth endoplasmic reticulum (SER) d. Golgi apparatus. e. vesicles 7. At which of the following would phenylalanine hydroxylase be chemically modified initially? a. ribosome. b. nucleus. c. Golgi apparatus. d. rough endoplasmic reticulum. e. vesicle. 8. The expression of phenylketonuria is a a. genotype, due only to the environment. b. genotype, due the interaction of genes and the environment. c. phenotype, due only to the environment. d. phenotype, due only to genes. e. phenotype, due the interaction of genes and the environment. 9. The Hardy-Weinberg Theorem predicts that the frequency of homozygous dominant individuals
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Bio final '07 - Biology 195Z 12/11/07 FINAL EXAM Please...

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