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Unformatted text preview: 2. T = A; C = G 3. T + A does not necessarily = C + G and changes from organism to organism. 4. c. Structure (Watson and Crick, 1953) 1. Experimental approach by X-ray crystallography (Franklin and Wilkins) 2. Model building (Watson and Crick) d. Relationship between structure and function. III. Chemical composition of RNA a. Sugar = ribose b. Thymine replaced by uracil IV. Denaturation/Renaturation of DNA a. melting temperature is directly proportional to base composition. b. kinetics of renaturation is related to concentration: single vs. multi-copy genes. Reading in 8 th edition Chapter 3, 80-90; in 9 th edition Chapter 2, 33-36 V. Higher order structure of DNA a. Nucleosomes b. Nuclear architecture c. Euchromatin and heterochromatin d. Structural elements of chromosomes 1. origins of replication 2. centromeres 3. telomeres 4. single copy vs. repetitive DNA...
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- Spring '09
- DNA, Crick, edition Chapter, Outline06Lectures11-12 DNA Structure, DNA a. building