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Outline11Lectures20-21

Outline11Lectures20-21 - BIS101/Engebrecht Spring2010...

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BIS101/Engebrecht Spring2010 Outline11; Lectures 20-21 Gene Mutations, DNA Repair, Recombination and Cancer Mutations are heritable changes in the DNA sequence. Mutations can be caused by many different means (spontaneous, induced, transposition). Mutagenesis is the only process that produces novel genetic information. Other mechanisms that enhance genetic diversity like recombination and meiotic chromosome segregation mix existing genetic information into novel combinations. Reading in 8 th edition Chapter 14, 451-472; in 9 th edition Chapter 15, 513-540 I. The relationship between DNA damage and mutation a. DNA damage = any modification of the DNA that alters the chemical structure of the DNA double helix (excluding modifications encoding by the organism like methylation) b. Mutation = a heritable change in the DNA sequence . Mutations do not affect the chemical structure of the DNA but the sequence of the normal bases. II. Adaptive versus preexisting mutation a. Adaptive = organisms adapt to environment and pass this adaption to their offspring b. Preexisting = mutations are random and natural selection acts upon them Luria and Delbruck experiment III. Types of mutations a. Germline vs. somatic- only germline mutations are inherited to offspring.
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