Outline12Lectures22

Outline12Lectures22 - BIS101/Engebrecht Spring2010 Outline12Lecture22 Chromosome Mutations-Structure and Number Changes in chromosome structure by

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BIS101/Engebrecht Spring2010 Outline12Lecture22 Chromosome Mutations-Structure and Number Changes in chromosome structure by mutations, whether spontaneous or induced, are of great importance to the field of genetics as well as medicine. Chromosomal mutations are used as tools in genetic experiments. In addition, many human diseases, including many types of cancer, are caused by chromosomal rearrangements. Reading in in 8 th edition Chapter 15, 496-509; in 9 th edition Chapter 16, 572-590. I. Deletion= non-revertable mutation that removes part of a chromosome (these can be small or large). Deletions are also referred to as deficiencies , meaning a piece of the chromosome is missing. a. Cytological detection of deletions in Drosophila b. Mapping genes using deficiencies- see Handout25DeficiencyMapping II. Duplication = duplicates parts of a chromosome a. Identification of duplications- the BAR locus of Drosophila b. Human globin gene duplication III. Inversion = structural aberration of a chromosome where an entire segment is
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This note was uploaded on 07/02/2010 for the course BIS BIS 101 taught by Professor Sanders during the Spring '09 term at UC Davis.

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Outline12Lectures22 - BIS101/Engebrecht Spring2010 Outline12Lecture22 Chromosome Mutations-Structure and Number Changes in chromosome structure by

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