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Unformatted text preview: Autosomal dominant 1. Affected children have at least one affected parent. 2. Usually 1/2 children are affected. Most dominant disease traits are rare so most affected individuals are heterozygotes. 3. Equal numbers of affected males and females. 4. Except for the very rare case of a new mutation, unaffected parents do not produce affected children (or the disease is not fully penetrant). e.g., Huntington corea, polydactyly, brachydactyly X-linked dominant 1. Affected males have daughters that are all affected. 2. Affected heterozygous females pass the disease to 1/2 sons and 1/2 daughters. Most dominant disease traits are rare so that most affected individuals are heterozygotes. e.g. Hypophosphatemia...
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- Spring '08