Handout18EuvsPro - no modifications of mRNA 3 poly (A) tail...

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BIS101/Engebrecht S10 Handout18 Transcription and other processes at the RNA level EUKARYOTES PROKARYOTES monocistronic monocistronic and polycistronic Initiation TATA box at around -25 in most genes -10 and -35 sites for RNA polymerase and sigma factor binding 3 dedicated RNA polymerases 1 RNA polymerase many accessory factors different types of sigma factors enhancers and silencers for complex promoter and operator less complex and close to mRNA start combinatorial transcriptional regulation acting at a distance and 5’ or 3’ of mRNA start RNA processing 5’ 7-methylguanosine cap in mRNA
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Unformatted text preview: no modifications of mRNA 3 poly (A) tail in most mRNAs introns and splicing no introns, no splicing RNA transport from nucleus to cytoplasm no RNA transport Termination RNA polymerase termination mechanism unclear rho-dependent and rho-independent termination cleavage of mRNA at AAUAAA signal Translation and other processes at the protein level spatially uncoupled from transcription tightly coupled with transcription 5 cap mediates ribosome binding Shine-Dalgarno sequence mediates ribosome recognition extensive post-translational modification of proteins much less post-translational modification...
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