Unformatted text preview: bile acid? FXR also promotes the efflux of bile acids by inducing the expression of which enzymes (give three examples and write out the full name! )? 5. CAR is a nuclear receptor for xenobiotic response. How does phenobarbital induce CAR-mediated CYP2B transcription? 6. How does CAR activation lead to tylenol (acetominophen/APAP) toxicity? What molecule can protect the liver from CAR-mediated APAP toxicity and why? 7. Are CAR knockout mice sensitive to phenobarbital-induced APAP toxicity? Why?...
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- Spring '04
- Bile acid, Nuclear receptor, estrogen receptor, HRE