F09studyques13_NuclearReceptors - bile acid FXR also...

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NST110 Fall 2009 Nuclear Receptors Study Questions 1. Definitions a. zinc finger b. agonist/antagonist c. orphan receptor d. physiological ligand e. hsp90 f. HRE 2. Compare and contrast type I and type II nuclear receptors. Describe their localization and dimerization characteristics and give a few examples of each type. 3. What are selective receptor modulators? How does tamoxifen, an estrogen receptor ligand, display this? 4. FXR is a nuclear receptor for bile acids, and acts as a regulator of bile acid homeostasis (the body needs to know when bile acid levels are too high, and by binding bile acids, FXR, can “sense” this). Which bile acid synthesis enzyme does FXR inhibit? And what is the precursor to
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Unformatted text preview: bile acid? FXR also promotes the efflux of bile acids by inducing the expression of which enzymes (give three examples and write out the full name! )? 5. CAR is a nuclear receptor for xenobiotic response. How does phenobarbital induce CAR-mediated CYP2B transcription? 6. How does CAR activation lead to tylenol (acetominophen/APAP) toxicity? What molecule can protect the liver from CAR-mediated APAP toxicity and why? 7. Are CAR knockout mice sensitive to phenobarbital-induced APAP toxicity? Why?...
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