Digoxin main cardiac effects are:-A decrease of conduction of electrical impulses through the AV node, making it a commonly used antiarrhythmic agent in controlling the heart rate.-An increase of force of contraction via inhibition of the Na+/K+ ATPase pump-Digoxin binds to a site on the extracellular phase of the α-subunit of the Na+/K+ ATPase pump in the membranes of heart cells and decreases its function. inhibition of the Na+/K+ pump leads to increased intracellular Na+ levels (and corresponding decreased extracellular Na+
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