plant toxin 2009-supp - Digoxin main cardiac effects are:...

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Digoxin main cardiac effects are: -A decrease of conduction of electrical impulses through the AV node, making it a commonly used antiarrhythmic agent in controlling the heart rate. -An increase of force of contraction via inhibition of the Na+/K+ ATPase pump -Digoxin binds to a site on the extracellular phase of the α -subunit of the Na+/K+ ATPase pump in the membranes of heart cells and decreases its function. inhibition of the Na+/K+ pump leads to increased intracellular Na+ levels (and corresponding decreased extracellular Na+
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