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Unformatted text preview: pies (methadone) • Glutamate appears to be the main neurotransmitter involved in craving. • Abstinent cocaine users shown video of either Nature (neutral) or Crack paraphernalia/drug taking. Neurotransmitters and Craving N @ eurotransmitters and Craving Glutamate Neurotransmission Triggers Craving Studies in Humans (PET) G @ lutamate Neurotransmission Triggers Craving Studies in Humans (PET) Associations With Drugtaking Stimulates Glutamate Transmission to A @ ssociations With Drugtaking Stimulates Glutamate Transmission to Nucleus Accumbens • Anterior cingulate cortex and amygdala neurons contain glutamate which signals to neurons in the nucleus accumbens • Glutamate is involved with learned associations with the drugtaking environment Effective Treatments for Addiction E @ ffective Treatments for Addiction • Glutamate in the nucleus accumbens triggers craving in abstinent individuals...
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