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Unformatted text preview: sion in the nucleus accumbens (NA) Striatum - stereotypy (repetitive movement) Side Effects of Stimulant Use Acute (short term) • • • Seizures Depression & Anxiety Psychosis (particularly higher doses in some) Chronic (Long term) • • • • • Anxiety Paranoia Depression Psychosis Neurotoxicity Narcotics Narcotic: induces narcosis (sleep or stupor) = numbing • • • • • • • Opium, Heroin (metabolised to morphine in CNS) Morphine Methadone Fentanyl Hydromorphone Meperidine Codeine Major Effects of Opiates • • • Euphoria and wellbeing Drowsiness Relief of pain Opiates Activation of mu opiate receptors directly act in the NA and indirectly stimulate dopamine release in the NA by cells in the VTA (mu & delta opiate receptors) Opiates (Morphine) Opiates bind to: • • • • Cortex: movement/sensory Cingulate cortex: judgement Thalamus & Spinal Cord : pain centre analgesia Side Effects of Opiate Use • • • • Chronic constipation Tolerance and withdrawal symptoms when stop use Coma/death from OD due to low tolerance Coma/death due to mix with depressants Consciousnessaltering Hallucinogens/psychedelics: produce hallucinations Hallucinogens/psychedelics: • • • • • • • MDMA (“E”) Lysergic Acid Diethylamide (LSD “Acid”) 2,5dimethoxy4iodoamphetamine (DOI) Phencyclidine (PCP, “angel dust”) Psilocybin (“magic” mushrooms) Mescali...
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This note was uploaded on 07/06/2010 for the course ANTHRO ANTH106 taught by Professor Lisawynn during the Three '10 term at Macquarie.
- Three '10