mycampbell43 - Functions of the immune system Protection...

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Functions of the immune system Protection against invading pathogens Bacteria,viruses,fungi,protozoans,tapew orms Remove dead or damaged cells Detect and remove abnormal cells Cancer cells
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The body’s defense system Physical and chemical barriers Innate immunity Leukocytes destroy invaders Response the same for all foreign invaders Not antigen-specific Clears or contains infection until acquired immune response can take over Acquired immunity
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The body’s defense system Acquired immunity Antigen-specific responses Lymphocyte-mediated Each foreign invader produces specific response
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Innate Immunity of Invertebrates In insects, an exoskeleton made of chitin forms the first barrier to pathogens The digestive system is protected by low pH and lysozyme , an enzyme that digests microbial cell walls
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Innate Immunity of Invertebrates Hemocytes circulate within hemolymph and carry out phagocytosis , the ingestion and digestion of foreign substances including bacteria
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Innate Immunity of Invertebrates Hemocytes also secrete antimicrobial peptides that disrupt the plasma membranes of bacteria Activated peptide expressing GFP lights up upon infection
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Lymphoid tissues of the immune system Primary lymphoid tissues : Immune cell formation and maturation Thymus gland: Produce T-lymphocytes Bone marrow: Produces most white blood cells Secondary lymphoid tissues : Interaction with target Spleen Lymph nodes Tonsils GALT (gut-associated lymphoid tissues)
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Figure 24-2a
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Figure 24-4 - Overview (1 of 7)
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Figure 24-4 (2 of 7) Basophils and mast cell Involved in inflammatory response Release histamine and heparin Involved in allergic reactions
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Figure 24-4 (3 of 7) Neutrophils Most abundant white blood cell Ingest and kill bacteria Release cytokines involved in inflammation
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Figure 24-4 (4 of 7) Eosinophils Cytotoxic cells that release cytotoxic substances that kill invading parasites Involved in allergic reaction and inflammation
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Figure 24-4 (5 of 7) Monocytes and Macrophages Monocytes mature into macrophages Primary scavenger phagocytes in tissues Antigen-presenting cell
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Figure 24-4 (6 of 7) Lymphocytes Responsible for acquired immunity Antigen-specific immunity B lymphocytes Antibodies T lymphocytes
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Dendritic cells Major Antigen-presenting cell Activates lymphocytes
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This note was uploaded on 07/07/2010 for the course BIOLOGY bild 2 taught by Professor Schroeder during the Spring '09 term at UCSD.

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mycampbell43 - Functions of the immune system Protection...

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