case02 - Case 2 Histidine-Proline-rich Glycoprotein as a...

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1 Case 2 Histidine-Proline-rich Glycoprotein as a Plasma pH Sensor Focus concept A histidine-proline-rich glycoprotein may serve as a plasma sensor and regulate local pH in extra- cellular fluid during ischemia or metabolic acidosis. Prerequisites C Acidic/basic properties of amino acids C Amino acid structure and protein structure Background This study focuses on the characteristics of the abundant plasma protein referred to as histidine- proline-rich glycoprotein (HPRG). HPRG is so named because it has a very high content of histidine (13 mol %). The human HPRG contains a pentapeptide GHHPH sequence repeated in tandem twelve times. The authors of this study hypothesized that its high histidine content might allow HPRG to play a role in regulating local pH in the blood. The local pH in blood may drop a half a pH unit during lactic acidosis or even a full pH unit in hypoxia or ischemia. In the case presented here, the binding of HPRG to glycos- aminoglycans was investigated. Glycosaminoglycans are anionic polysaccharides that are the major component of the ground substance that forms the matrix of the extracellular spaces of the connective
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This note was uploaded on 07/07/2010 for the course BIOL 237 taught by Professor Daragilbert during the Fall '09 term at Waterloo.

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case02 - Case 2 Histidine-Proline-rich Glycoprotein as a...

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