amino_acids_F09_with_copious_scribbles

amino_acids_F09_with_copious_scribbles - Chemistry 237...

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Chemistry 237 Amino Acids
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mino Acids Amino Acids general formula structures and properties titration curves optical activity on- tandard amino acids non standard amino acids Reactions involving amino acids
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The 20 protein amino acids are called - mino acids α amino acids neutral form of an α -amino acid zwitterionic form of an α -amino acid Why α -amino acids ? ecause the NH roup is on the Because the NH 3 group is on the alpha carbon. The carbon next to a carbonyl group is called the alpha ( α )-carbon, then the β - carbon, γ -carbon, etc. O O-
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mino acids Amino acids mino acids can act as an acid or a base. Amino acids can act as an acid or a base. -COOH H 2 N-
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Alphabetical list of the 20 amino acids You are expected to know the structures of the 20 protein mino acids amino acids The single letter amino acid code is not necessary but is VERY USEFUL!
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cideroids Acideroids ttp://www.wiley.com/legacy/college/boyer http://www.wiley.com/legacy/college/boyer /0470003790/animations/acideroids/acider oids.htm aution: This game will teach you to Caution: This game will teach you to recognize the 20 common amino acids. You must also be able to draw them, and know the pKa and three and single letter codes.
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Classifying the Amino Acids NON-POLAR POLAR Small side chain: Gly, Ala Uncharged polar side chains: Ser, Thr, Tyr, Gln, Asn Branched-chain: Val, Ile, Leu Charged polar side chains: Aromatic side chains: Phe, Trp (Tyr) Lys, Arg, His (positive charge) Asp, Glu (negative charge)
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One other variant: cystine (disulfide of Cys): Cystine
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cid- ase Properties Acid Base Properties mino acids are polyprotic weak acids Amino acids are polyprotic weak acids. Each ionizable group has a characteristic pK a . Each ionizable group has a characteristic titration profile.
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1 st ionization pKa ~2.2 2 nd ionization pKa ~9.5
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titration curve of Gly Endpoint of COOH titration
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Titration curves of peptides ave ne plateau r each ionizable Have one plateau for each ionizable group The only groups to titrate are the N- terminal, the C-terminal and the side chains
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p K a values of the 20 amino acids --the p K a of the -COOH is about 2.2
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This note was uploaded on 07/07/2010 for the course BIOL 237 taught by Professor Daragilbert during the Fall '09 term at Waterloo.

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amino_acids_F09_with_copious_scribbles - Chemistry 237...

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