LEC 13 Concepts of Metabolism

LEC 13 Concepts of Metabolism - SYNTHESIS OF LIVING MATTER:...

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SYNTHESIS OF LIVING MATTER: THE ROLE OF INFORMATION ! The synthesis of all the components of a cell requires ! 4,000 types of proteins ! Each type of protein is unique in function ! Therefore each protein is unique in 3- dimensional structure ! Each protein is also unique in amino acid sequence ! Therefore, each cell must be able to arrange amino acids into polypeptide chains in ! 4,000 ways ! This requires “instructions”,"information”,”genes”
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Connecting information with DNA: First evidence 1800's: focus on the nucleus of (eucaryotic) cells ! central position ! uniqueness ! special handling of chromosomes during cell reproduction. Nucleus and DNA connection ! Friederich Miescher, biochemist ! 1869, Tubingen castle ! Used pus cell nuclei to isolate “nuclein” Nuclein ! acidic (- charge at cell pH) ! Contains C,H,O,N, and 10%P ! Polymer of 4 subunits ! Stringy material of high MW.
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Evidence that DNA stores information: Transformation Objective: Identify information by a functional
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This note was uploaded on 07/08/2010 for the course BIS B16 taught by Professor Gerhart during the Winter '10 term at The University of British Columbia.

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LEC 13 Concepts of Metabolism - SYNTHESIS OF LIVING MATTER:...

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