LEC 14 Concepts of Metabolism

LEC 14 Concepts of Metabolism - Structure of DNA Watson and...

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Structure of DNA
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Watson and Crick use two sets of observations to infer the structure of DNA X-ray crystallography: DNA is a helix Subunit analysis
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Polymerization of DNA subunits by condensation Deoxyribose T
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Subunits of nucleic acids (RNA) (DNA)
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The double helix “Complementary” base pairs stick together through H-bonds Note: antiparallel
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The double helix The helical twist pulls the hydrophobic bases close together
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DNA chains can be very long ! E. coli chromosome: 4.6x10 6 base pairs: 4.6x 10 6 x .34 nm = 1.5x10 6 nm = 1.5 mm ! Human DNA: 6x10 -12 g/cell x 1/660 mol bp/g x 6.023x10 23 bp/mol bp x 0.34x10 -9 m/bp = 1.9 m ! Bacterial, viral DNA “chromosomes” are circles ! DNA in human chromosomes (and DNA of all eukaryotes) are linear strands ! “Z-DNA”, left-handed double helix, is also possible
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In eukaryotes, DNA chains coil to become shorter and thicker Centromere Telomeres
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Melting and re-association of DNA ! H-bonds are weak bonds, broken by high temperature ! DNA “melts”--strands separate--at 85-95
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LEC 14 Concepts of Metabolism - Structure of DNA Watson and...

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