LEC 17 Concepts of Metabolism

LEC 17 Concepts of Metabolism - MUTATIONS, MUTAGENESIS, AND...

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MUTATIONS, MUTAGENESIS, AND CARCINOGENESIS
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How do different alleles arise? Mutations: heritable changes in genes Mutations occur in DNA But their effects involve proteins Structural genes Silent Mis-sense Nonsense Frameshift Intron/exon boundaries Control genes Promoter/enhancer sequences Transcription factors Point mutations
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A base change that leads to a new codon for the same amino acid is a silent mutation.
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A base change that gives a codon for a different amino acid is a mis-sense mutation. Original sequence:
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A base change that produces premature termination (from new UAA, UAG, or UGA codons) is a nonsense mutation. Original sequence:
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The addition or deletion of a base (or 2 bases) produces a frame-shift mutation. Original sequence:
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Spontaneous base changes (tautomerization) Errors at replication Chemical reactions Reactive oxygen ( 1 O 2 , O 3 , . OH, HNO
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This note was uploaded on 07/08/2010 for the course BIS B16 taught by Professor Gerhart during the Winter '10 term at The University of British Columbia.

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LEC 17 Concepts of Metabolism - MUTATIONS, MUTAGENESIS, AND...

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