LEC 19 Regulating Protein Synthesis -- Eukaryotes

LEC 19 Regulating Protein Synthesis -- Eukaryotes -...

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REGULATION OF PROTEIN SYNTHESIS II. Eukaryotes
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Complexities of eukaryotic gene expression ! Several steps needed for synthesis of mRNA ! Separation of transcription and translation ! Compartmentation of proteins
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Why is eukaryotic gene expression complex? ! Archaea provided genes for DNA metabolism, transcription, translation, DNA repair ! Bacteria provided genes for carbohydrate, amino acid, lipid metabolism ! Some bacterial genes persist in mitochondria, chloroplasts
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Complexities of eukaryotic gene expression ! Epigenetics: which genes are expressed? DNA methylation Histone modification siRNA gene silencing ! Several steps needed for synthesis of mRNA Uncoiling of chromatin Remodeling of chromatin Transcription Transcript processing
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DNA must uncoil to be used as a template Long-term vs short-term Development
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Evidence for the uncoiling of chromosomes “Lampbrush chromosomes from Axilotl ova Chromosome puffs in Drosophila salivary glands
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Remodeling Removal of histones Initiation of transcription
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LEC 19 Regulating Protein Synthesis -- Eukaryotes -...

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