LEC 24 Regulating Protein Synthesis -- Eukaryotes

LEC 24 Regulating Protein Synthesis -- Eukaryotes - ORIGIN...

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ORIGIN OF CELLULARITY AND CELLULAR DIVERSITY
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Last impact heating ~3500 Geological stratigraphy, together with radioactive dating, show the sequence of events in the history of the Earth. Note the entry for “cyanobacteria” and “stromatolites” only one billion years after the formation of the Earth. But what came before them? And how did cells become more complicated 1.5 B years later?
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Chemical experiments, initiated by Stanley Miller and Harold Urey, Showed that some biochemicals could be formed naturally (but not all--where did the rest come from?) Life starts with chemistry
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Protobionts vs. surface layers What is important about a cell? How would you start, if you wanted to make a model of a cell? Hypothesis: Metabolism (energy, reproduction) needs a way of concentrating intermediates. Cells Adsorptive surfaces
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Protobionts: a step toward living cells? In 1957, Sidney Fox demonstrated that dry mixtures of amino acids could be encouraged to polymerize upon exposure to moderate heat. When the resulting polypeptides, or proteinoids, were dissolved in hot water and the solution allowed to cool, they formed small spherical shells about 2 μ m in diameter—microspheres. Under appropriate conditions, microspheres will bud new spheres at their surfaces.
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Tiny compartments in mineral structures can shelter simple molecules, while mineral surfaces can provide the scaffolding on which those molecules assemble and grow. Beyond these sheltering and supportive functions, crystal faces
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LEC 24 Regulating Protein Synthesis -- Eukaryotes - ORIGIN...

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