fulltext27 - Processing and Characterization of Gold...

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Processing and Characterization of Gold Nanoparticles for Use in Plasmon Probe Spectroscopy and Microscopy of Biosystems Y U C HEN , a , b J ON A. P REECE , c AND R ICHARD E. P ALMER b a Department of Physics, University of Strathclyde, Glasgow, United Kingdom b Nanoscale Physics Research Laboratory, School of Physics and Astronomy, University of Birmingham, Birmingham, United Kingdom c School of Chemistry, University of Birmingham, Birmingham, United Kingdom Noble metal nanoparticles have great potential for applications in biochemical sensing and bio- logical imaging because of their unique optical properties originating from the excitation of local surface plasmon resonances. We investigated gold nanoparticles with controlled size, shape, and passivating agents, along with a new process of guided self-assembly to create two-dimensional nanostructures from such nanoparticles. Key words: nanoparticles; nanoclusters; synthesis; processing; surface plasmon Introduction Noble metal nanoparticles have great potential for applications in biochemical sensing and biolog- ical imaging because of their unique optical prop- erties originating from the excitation of local sur- face plasmon resonances (LSPRs). 1–3 The highly confined local electric field enhancement that accom- panies the excitation of LSPRs has been used in a vari- ety of near-field enhanced spectroscopy and imaging modes, from near-field scanning optical microscopy to surface-enhanced Raman spectroscopy. 4–6 Moreover, enhancement of fluorescence by using near-field ef- fects has been achieved in single-molecule experiments and planar dye layers with adsorbed nanoparticles. 7–9 Among noble metal particles, gold nanoparticles have attracted intensive interest because they are easily pre- pared, have low toxicity, and can be readily attached to molecules of biological interest. 10 The surface plasmon resonance is a coherent oscil- lation of the surface conduction electrons excited by electromagnetic radiation. It is sensitive to local dielec- tric environment. 11–13 Typically, LSPR devices sense changes in the local environment through a resonance wavelength shift. Apart from the environmental effect, Address for correspondence: Yu Chen, Department of Physics, Uni- versity of Strathclyde, John Anderson Bldg., 107 Rottenrow, Glasgow G4 0NG, UK. Voice: + 0044 141 548 3087; fax: + 0044 141 552 2891. y.chen@strath.ac.uk the LSPR of nanoparticles is dramatically affected by their size, shape, and surface modifications. Therefore, one can tune the LSPR wavelength throughout the visible, near-infrared, and infrared region of the elec- tromagnetic spectrum by careful control over the syn- thetic process to vary the nanoparticle shape, size, and encapsulation. We investigated gold nanoparticles with controlled size, shape, and passivating agents, along with a new process of guided self-assembly to create two-dimensional nanostructures from such nanoparti- cles. Synthesis of Gold Nanoparticles
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fulltext27 - Processing and Characterization of Gold...

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