Synthesis Shortcuts

Synthesis Shortcuts - PBr 3/Et 2 O I(CH 3 2 CHBr(II Mg/Et 2...

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Hello, There will be at least one synthesis problem on the next exam and on the final exam. The purpose of this email is to help you answer such problems as clearly as possible. Usually a synthesis is a series of steps in which a starting compound is converted to a product that is then converted to another product, until eventually the final product is reached. Sometimes still another starting compound may also be converted to a product that is then reacted with one of the products from the other starting material. To present a synthesis in a clear way requires that for each step you identify the reactant, the product, the reagents (including solvent), and any work up (e.g. H 2 O/H + ). For example, consider this synthesis of 2,3-dimethyl-2-butanol from acetone: 1-LiAlH 4 /Et 2 O (CH 3 ) 2 C=O (CH 3 ) 2 CHOH (I) 2-H 2 O/H + Now if you want to use the product of the first step in a second step it is easier to designate it by a roman numeral, as shown above, rather than rewriting it. For example.
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Unformatted text preview: PBr 3 /Et 2 O I (CH 3 ) 2 CHBr (II) Mg/Et 2 O II (CH 3 ) 2 CHMgBr (III) III + (CH 3 ) 2 C=O (CH 3 ) 2 C(OH)CH(CH 3 ) 2 H 2 O/H + To summarize. When presenting a synthesis on an exam use this format: a. Put reagents and solvents above the arrow, put the work up (if there is one) below the arrow. Separate reagents from each other with commas and from solvents with a slash (/). b. Once you write the structure of a compound you can designate it with a roman numeral and then use the numeral instead of writing the structure again. It’s easier for the grader and easier for you. Good luck on the exam. Robert Boikess Pat O’Connor Heinz Roth P.S. If you feel that the above synthesis would be very difficult for you to devise, you need to spend more time learning and understanding the reactions we have presented and you need to practice more synthesis problems....
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This test prep was uploaded on 04/03/2008 for the course CHEM 308 taught by Professor Boikess during the Winter '08 term at Rutgers.

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Synthesis Shortcuts - PBr 3/Et 2 O I(CH 3 2 CHBr(II Mg/Et 2...

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