07 lecture_Fiehn BIS103 PPP and gluconeogenesis_winter 2009

07 lecture_Fiehn BIS103 PPP and gluconeogenesis_winter 2009...

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Reducing power for anabolic reactions: NADPH which is delivered by the Pentose Phosphate Pathway Amino acids Amino acids Galactose Mannose Fructose PDH Glucose can be stored, oxidized or serve as substrate for anabolic reactions , NADPH
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Pentose Phosphate Pathway looks complex – because it gives a lot of metabolic flexibility to the cell ! stage I stage II stage III Pentose Phosphate Pathway looks complex – because it gives a lot of metabolic flexibility to the cell ! stage II stage III 21 2 1 3 3 6 6 H + stage I 3 6 NADP + Overall net reaction 3 G6P + 6 NADP + + 3 H 2 O Æ 6 NADPH + 6 H + + 3CO 2 + 2 F6P + GAP
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Pentose Phosphate Pathway Æ STAGE 1 is irreversible, determines flux into PPP, generates 2 NADPH and 1 Ru5P from 1 G6P hydrol. Pentose Phosphate Pathway produces NADPH and ribose-5P Ribose-5P is the substrate for Histidine and nucleotides, but Xu5P is not! stage II stage I phosphopentose epimerase
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Pentose Phosphate Pathway looks complex – because it gives a lot of metabolic flexibility to the cell !
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07 lecture_Fiehn BIS103 PPP and gluconeogenesis_winter 2009...

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