09th lecture_Fiehn BIS103 glycogen metabolism_winter 2008

09th lecture_Fiehn BIS103 glycogen metabolism_winter 2008 -...

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Glycogen metabolism
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Glycogen
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Glycogen metabolism: separate pathways for synthesis and breakdown
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Glycosylation (glycogen synthesis) ATP + UDP ÅÆ UTP + ADP Glycogenin initiates glycogen synthesis UDPG + Æ gluc ÆÆ gluc 7 G G G
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Glycosylation (glycogen synthesis)
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Glycogen synthesis
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Glycogen structure is determined by branching enzyme
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Glycogen breakdown is performed by Phosphorylase Vitamin B 6 derivative covalently bound by Schiff base (imine) Glycogen breakdown 1. Glycogen phosphorylase n glycogen + P i Æ n -1 glycogen + G1P 2. Glycogen debranching enzyme 3. Phosphoglucomutase G1P ÅÆ G6P
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Primary glycogen breakdown by Phosphorylase
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Further glycogen breakdown by debranching enzyme
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Final glycogen breakdown by Phosphoglucomutase Reverse of glycolysis hexokinase G6P Æ glucose by Glucose-6-Phosphatase G6Pase in the liver ER involves specific translocase and transporters back to cytosol for glucose and Pi
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Glycogen breakdown/synthesis: flux control by allosteric regulation activation AMP inactivation G6P, ATP activation G6P, ATP inactivation AMP
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09th lecture_Fiehn BIS103 glycogen metabolism_winter 2008 -...

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