Biology_200_final_2003

Biology_200_final_2003 - Biology 200 final 2003 - Section...

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Biology 200 final 2003 - Section 102 - Berger This examination is worth 100 marks. You will have two and a half hours. Please be careful to budget writing time. 1. (6 marks, 6 minutes). Cells at the Anaphase B stage of mitosis are treated with a number of drugs. Indicate for each type of drug below whether there would be an effect, and indicate the likely consequence and explain why . If there would be no effect, write “no effect”. Write answer in exam booklet . An inhibitor of plus end motor proteins –Would block spindle elongation because the microtubules making up the continuous spindle fibers could not be pulled apart by kinesins (plus end motor proteins) do decrease the width of the zone of overlap in the middle of the spindle. The plus ends of the MTs are in the middle of the spindle. An inhibitor of minus end motor proteins – No effect An inhibitor of microtubule assembly – Would block spindle elongation because the microtubules of the continuous fibers elongate from the plus end before then can be drawn apart by motor proteins An inhibitor of microtubule disassembly – No effect Distribution of marks: 6 5 4 3 2 1 0 XXXXX XXXXX XXXXX XXXXX XXXXX XXX XXXXX XXXXX XXXXX XXXXX X XXXXX XXXX XXXXX XX XXXXX XX XX X 2. (20 marks, 20 minutes ). Discuss targeting of proteins in cells . Suggestions for writing this question : Start by making a list on scrap paper of examples of cellular structures or pathways to which proteins may be targeted. Think about the type of targeting processes associated with each of these. Can you see ways to group these phenomena into categories? What features are common to each category? Are there overall features shared by all or nearly all of your categories. From these considerations formulate an overall thesis and subsidiary theses for each category of phenomena. Are there exceptions to the general principles that you have established? Support your argument with specific details Marking : content 50%; theses, clarity and presentation 50%.
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In order for a protein to be targeted to a particular location in the cell, there are two major requirements that must be met. In all targeting, the protein must contain a signal sequence of some kind, to specify where the protein is targeted to, and a receptor of some kind that will recognize the particular signal that is specific to the receptor. Distribution of marks: 20 19 18 17 16 15 14 13 12 11 XXXXX XX XXXXX XXXX XXXXX XXXXX XXXXX X XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXXX XXXX XXXXX XXXXX XXXXX XXXX XXXXX XXXXX XXXXX XXXXX XX XXXXX XXXXX XXXXX XXXXX X XXXXX XXXXX XXXXX XXXXX XXX 10 9 8 7 6 5 4 3 2 0-1 XXXXX XXXX XXXXXXXXXXXXXXX XXX XXXXX XX XXXX XX XX X XX Student answer 1. In order for a protein to be targeted to a particular location in the cell there are two major requirements; that must be met. In all targeting the protein must contain a signal sequence of some kind to specify where the protein is targeted to (#), and
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Biology_200_final_2003 - Biology 200 final 2003 - Section...

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