10th lecture _Fiehn BIS103 fatty acid catabolism_winter 2008

10th lecture _Fiehn BIS103 fatty acid catabolism_winter...

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Overview about metabolism so far…. Amino acids Amino acids Galactose Mannose Fructose PDH Glycogen Lipids gluconeogenesis
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Fatty acid degradation and synthesis are linked to AcetylCoA
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Lipid metabolism
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Some major lipid classes
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Stored lipids are catabolized by phospholipase A2
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Food lipids are incorporated into chylomicrons for transport to organs
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Lipoproteins transport lipids through the body
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‘Chylomicrons’ are clearly visible after a meal !
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Along transport, lipoproteins change composition
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Along transport, lipoproteins change composition
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The liver is the organ of lipid metabolism
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Fatty acid degradation and synthesis are spatially separated
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Fatty acid β -oxidation releases energy through the TCA cycle and the electron transport chain
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Fatty acids need activation by CoASH for degradation
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Fatty acids need activation by CoASH for degradation
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Transport of fatty acid into mitochondria
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Each round of β -oxidation releases acetyl- CoA and a fatty acid that is 2 carbons shorter
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Fatty acids undergo β -oxidation Voet, Voet & Pratt
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Fatty acids undergo β -oxidation Lehninger
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10th lecture _Fiehn BIS103 fatty acid catabolism_winter...

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