Chapter 13 – Gene Expression

Chapter 13 - Chapter 13 Gene Expression I Discovery of the Gene-Protein Relationship a Enzyme is a protein i Alkapotunuria 1 Homogenitic acid

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I) Discovery of the Gene-Protein Relationship a. Enzyme is a protein i. Alkapotunuria 1. Homogenitic acid accumulates in urine 2. Tyrosine does not fully degrade into CO2 and water 3. Sumner found the enzyme to be urease and showed it to be a protein b. Beadle and Tatum – One Gene One Protein i. Chose neurospora as experimental organism 1. Wild-type a. Individuals with a normal phenotype ii. Revealed that each mutant strain had a mutation in only one gene and each gene affected only one enzyme c. Pauling and Ingram i. Pauling demonstrated that mutation in a single gene caused the change in shape of hemoglobin ii. Ingram expanded on that and found that one locus mutation on a chromosome produced a protein with one different amino acid d. One Gene is responsible for One Polypeptide II) Information Flow From DNA to Protein: An Overview a. DNA RNA Protein i. RNA is the link between DNA and Protein b. DNA is Transcribed To Form RNA i. Three Kinds of RNA
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This note was uploaded on 07/17/2010 for the course 119:102 119 taught by Professor Uzwiak during the Spring '09 term at Rutgers.

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Chapter 13 - Chapter 13 Gene Expression I Discovery of the Gene-Protein Relationship a Enzyme is a protein i Alkapotunuria 1 Homogenitic acid

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