LECT21a_Tissue Engineering

LECT21a_Tissue Engineering - Click to edit Master subtitle...

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Unformatted text preview: Click to edit Master subtitle style Tissue Engineering BME 410 30NOV2009 Evolution of Biomaterials First Generation (30-40 years back) Goal: Bioinertness Minimal interaction and reaction Second Generation Goal: Bioactivity Resorbable biomaterials; controlled reaction with physiological environment Third Generation Goal: Regenerative functional tissue Biointeractive, integrative, resorbable; Stimulate specific cell response at molecular level Tissue Engineering defined: n Application of principles and methods of engineering and life sciences toward the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and the development of biological substitute to restore, maintain, or improve tissue functions. n Goal of Tissue Engineering: to meet the task of regenerating tissue in vitro Tissue Engineering vs. Regenerative Medicine n Tissue Engineering n Regeneration in vitro n Regenerative n Regeneration in vivo Tissue ability to regenerate n Which tissues can n Muscle q Smooth q Cardiac (doesnt) and Skeletal n Nerve cant n Epithelia (to a certain extent) q Epidermis n Connective tissues n What can prevent n Limited vascularization of large defects (e.g. bone does not regenerate in center) n Collapse of tissue into defect (e.g. periodontal defects) n Excessive mechanical strains in reparative tissue Tissue Engineering Triad...
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This note was uploaded on 07/18/2010 for the course BME 410 taught by Professor Dr.love during the Fall '10 term at University of Michigan.

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LECT21a_Tissue Engineering - Click to edit Master subtitle...

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