2-4-10-PDF_40306 - Practice Can you draw the structure of...

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Can you draw the structure of fatty acid? Practice 18:2n-6 18:3n-6 20:4n-6 Ex.
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Lipid Classification A. Fatty Acids B. Triglycerides C. Glycerophospholipids D. Sphingolipids E. Steroids review
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1. Membrane Proteins A. Integral membrane proteins B. Lipid-linked proteins 2. Membrane structure and assembly A. The Fluid Mosaic model B. Membrane skeleton C. Lipid asymmetry D. The Secretory pathway 3. Transport across membranes A. Mechanisms of mediated transport B. Thermodynamics of Transport C. Active transport Membranes Lec 6 Lec 7 Introduction: Lipid bilayers
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Membranes Lecture 6 Membranes are a central to the structure and function of living cells 1. Membranes define inside and outside of cells. 2. Membranes define intercellular compartments . 3. They control all communications with the outside environment. 4. They control intracellular communications. 5. Involved in cellular defense and motility .
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On a aqueous surface lipids can form a monolayer but when surrounded the micelle forms monolayer micelle
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Lipids form structures when they interact with aqueous media. The hydrophobic nature of the nonpolar tails force water to be organized more so than usual. Entropy (of the water and system) is minimized when contact with water is minimized. Thus, the formation of structures. Lipid bilayers
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Lipid bilayers
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Lipid mobility, how far and in what direction can lipid molecules move Biological activity of membrane proteins is tied to how fast proteins can move in the membrane Lipids can move laterally or spin rapidly in the membrane but can not flip flop from one bilayer leaflet to another
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A change in the lipid physical state from the ordered gel phase, where the hydrocarbon chains are fully extended and closely packed, to the disordered liquid crystalline phase, where the hydrocarbon chains are randomly oriented and fluid. The phase transition temperature is defined as the temperature required to induce a change in the lipid physical state. Phase transition
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More ordered array A gel-like solid Highly mobile Phase transition
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All cells are surrounded by a plasma membrane made of phospholipids and proteins. Lipid bilayer
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Integral membrane proteins usually span the membrane. Many span the membrane several times.
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The functions of membrane proteins vary but many carry out transport processes , regulating the flow of molecules from one side of the membrane to the other.
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Glycophorin A found in red blood cells, a transmembrane protein. The GpA system has been studied by a variety of biochemical and biophysical techniques aimed at understanding the basis of this self-association; accordingly, GpA serves as a model for how analogous systems might be studied.
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Amino acid number from N-terminus Hydropathy plot to localize potential a - helical membrane- spanning segments in a polypeptide chain Identification of transmembrane domain
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The “hydropathy index” of the segment is plotted on the y axis as a function of its location in the chain (x axis).
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2-4-10-PDF_40306 - Practice Can you draw the structure of...

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