2-11-10-PDF_40539 - Electron transport and oxidative...

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Electron transport and oxidative phosphorylation Lec 8 Lec 9 1. The mitochondrion A. Mitochondrial anatomy B. Mitochondrial transport systems 2. Electron transport A. Thermodynamics of electron transport B. The sequence of electron transport C. Complex I NADH Coenzyme Q Oxidoreductase D. Complex II succinate Coenzyme Q Oxidoreductase E. Complex III Coenzyme Q-Cytochrome c Oxidoreductase F. Complex IV Cytochrome c oxidase
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3. Oxidative Phosphorylation A. The Chemiosmotic Theory B. ATP Synthase C. The P/O ratio D. Uncoupling oxidative phosphorylation 4. Control of ATP Production A. Control of oxidative phosphorylation B. Coordinated control of oxidative metabolism 5. Physiological implications of aerobic metabolism A. Cytochrome P450 B. Reactive Oxygen Species C. Antioxidant Mechanisms Lec 10 Lec 11
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Mitochondria and chloroplasts are organelles of energy conversion that carry their own DNA Mitochondria ± release energy from nutrients and convert it to ATP Chloroplasts ± capture solar energy and store it in carbohydrates
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Mitochondrion
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Size: 0.5 x 1.0 P m - similar size to Bacteria Copy number per cell: ~2000 Mitochondria Mitochondria are membrane-enclosed organelles distributed through the cytosol of most eukaryotic cells. Their main function is the conversion of the potential energy of food molecules into ATP . Every type of cell has a different amount of mitochondria . There are more mitochondria in cells that have to perform lots of work, for example - your leg muscle cells, heart muscle cells etc. Other cells need less energy to do their work and have less mitochondria.
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Particles : portion of integral membrane proteins
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The inner membrane has many more proteins than the outer membrane
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Note the large surface area of the cristae Cristae are sometimes tubular and are connected to the inner membrane space through small holes that restrict the flow of protons . This restriction causes an increase in the pH gradient and increases the ATP production . Note that there are attachment sites from the outer to the inner membrane. These allow the proteins to be imported directly into the matrix.
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A human mitochondrial genome database http://www.mitomap.org/ Supplemental
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The size and gene content of mtDNA vary from organism to organism Supplemental
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Mitochondrial DNA Map Supplemental
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Human mtDNA migrations Supplemental
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Mitochondrial and nuclear DNA stained with a fluorescent dye mt DNA nuclear mt Cell Supplemental
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Production of mitochondrial (and chloroplast) proteins Supplemental
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Codon Usage (standard code) Supplemental
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Codon Usage Supplemental
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Mitochondria have their own DNA
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This note was uploaded on 07/20/2010 for the course BCHS BCHS 3305 taught by Professor Fujita during the Spring '10 term at University of Houston.

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2-11-10-PDF_40539 - Electron transport and oxidative...

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