Unformatted text preview: to the amide nitrogen of asparagine side chains. O-linked glycosylation: to the hydroxyl oxygen of serine and threonine side chains. • More for regulation o Glycosylation serves various functions: Some proteins do not fold correctly unless they are glycosylated first. Polysaccharides linked at the amide of nitrogen of asparagine confers stability of some secreted glycoproteins… where unglycosylated proteins are quickly degraded. Cell adhesion. • A protein may be anchored to the membrane if it is attached with lipid molecules. II. Regulation of Protein Function • Regulation of protein activity by kinase / phosphatase switch. o Phosphorylation changes a protein’s charge and generally leades to a conformational change—which may lead to activation or inactivation of the protein function. o Ooooooo used in the kinase/phosphatase switch....
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- Summer '07
- Collagen, Posttranslational modification, I. Post-Translational Protein