SN2 pathways - mechanism Br Br N + OH H N H H NH 2 SH + KOH...

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General S N 2 Pathways 1) Acid Catalyzed : Acid will activate the leaving group OH KBr + H 2 SO 4 a) Nucleophile is a non-basic salt mechanism OH H OH 2 Br Br + H 2 O b) Neutral nucleophile OH KBr + H 2 SO 4 mechanism OH H OH 2 O OH + H 2 O H -H O 2) Base Catalyzed : Base will activate the nucleophile NH 2 + KOH a) Added base is weaker than the conjugate base of the nucleophile
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Unformatted text preview: mechanism Br Br N + OH H N H H NH 2 SH + KOH b) Added base is stronger than the conjugate base of the nucleophile mechanism Br Br S S S OH H S N 2 S N 2 S N 2 S N 2...
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This note was uploaded on 07/21/2010 for the course SCIENCE CHM 1321 taught by Professor Ogilvie during the Winter '09 term at University of Ottawa.

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