bio12 - BIO 1140 TOPIC 12 SLIDE 1 TOPIC 12 THE...

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TOPIC 12 SLIDE 1 BIO 1140 TOPIC 12: THE EXTRACELLULAR MATRIX ± that ‘stuff’ outside the plasmalemma ± ANIMALS ± no cell wall! ± glycocalyx - CHO layer right next to membrane – both the ECM CHOs and those attached to integral proteins are part of basal lamina ± glycosaminoglycans (GAGs) – are the most anionic molecules produced by animal cells), fibrous and adhesive proteins ± PLANTS ± cell wall of cellulose (equivalent to glycocalyx of animals) ± BACTERIA ± cell wall of peptidoglycan (equivalent to glycocalyx) ± gram-positive and gram-negative 2 3 TOPIC 12 SLIDE 2 BIO 1140 extracellular matrix cell membrane CYTOPLASM THE ‘STUFF’ OUTSIDE THE PLASMA MEMBRANE 19 TOPIC 12 SLIDE 3 BIO 1140 THE EXTRACELLULAR MATRIX ± Secreted and organized locally ± fibroblasts ± ± Many types ± basal lamina (basement membrane) ± calcified as in bone ± clear as in cornea ± ± cell walls of plants and bacteria ± shells of mollusks 18 17
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TOPIC 12 SLIDE 4 BIO 1140 ANIMAL EXTRACELLULAR MATRIX ± TWO MAIN TYPES OF MACROMOLECULES ± (1) POLYSACCHARIDE CHAINS ± proteoglycans ± glycosaminoglycans (GAGs) covalently linked to proteins forming proteoglycans (95% CHO by weight) ± one of the sugar residues in the repeating disaccharides is either N-acetylglucosamine or N- acetylgalactosamine ± hydrated gel-like material designed to resist compression
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bio12 - BIO 1140 TOPIC 12 SLIDE 1 TOPIC 12 THE...

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