13 Connections - BIO 1140 Topic 13 Slide 1 EMPTY BIO 1140...

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BIO 1140 Topic 13 Slide 1 EMPTY BIO 1140 Topic 13 Slide 2 THREE PRINCIPAL TYPES 1. OCCLUDING (or SEALING) 2. ADHESIVE (or ANCHORING) 3. COMMUNICATING TOPIC 13: CELL CONNECTIONS BIO 1140 Topic 13 Slide 3
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BIO 1140 Topic 13 Slide 4 OCCLUDING JUNCTIONS (SEALING JUNCTIONS) ¾ SEAL CELLS TOGETHER IN EPITHELIA ¾ General concepts concerning epithelia ¾ Interstitial space ¾ Epithelium vs membrane ¾ Transmembrane vs transepithelial ¾ Apical vs basolateral ¾ Tight junctions (tj) BIO 1140 Topic 13 Slide 5 Intestinal epithelium APICAL SURFACE (LUMEN OF GUT) BASAL (BASOLATERAL SURFACE) (BLOOD) transmembrane transmembrane intra cellular paracellular (inter cellular) transepithelial epithelia are polarized BIO 1140 Topic 13 Slide 6 TIGHT JUNCTIONS ¾ an occluding junction ¾ primarily a permeability barrier ¾ blocks paracellular route ¾ claudins (> 24 types) are the main protein involved with occludins also present but of unknown function ¾ differences between tight junctions (t.j.): in small intestine 10,000 X more leaky to Na+ than t.j. in urinary bladder ¾ Also help to rectify proteins on epithelia (e.g. of how membrane protein asymmetry is maintained) Next slide Slide 8
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BIO 1140 Topic 13 Slide 7
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This note was uploaded on 07/21/2010 for the course SCIENCE BIO1140 taught by Professor Fenwick during the Winter '09 term at University of Ottawa.

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13 Connections - BIO 1140 Topic 13 Slide 1 EMPTY BIO 1140...

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