15 Replication - BIO 1140 TOPIC 15 SLIDE 1 TOPIC 15...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 1140 TOPIC 15 SLIDE 1 TOPIC 15: REPLICATION ¾ THE DUPLICATION (SYNTHESIS) OF DNA 1. SEMICONSERVATIVE 2. BIDIRECTIONAL ¾ REPLICATION ORIGIN & REPLICON ¾ REPLICATION COMPLEX ¾ THE PROCESS ¾ THE ENDS OF CHROMOSOMES (TELOMERES) BIO 1140 TOPIC 15 SLIDE 2 THE CENTRAL DOGMA OF MOLECULAR BIOLOGY ¾ relates to the direction of information flow ¾ DNA Î RNA Î protein DNA ¾ Replication: DNA Î DNA ¾ Transcription: DNA Î RNA ¾ Translation RNA: Î protein BIO 1140 TOPIC 15 SLIDE 3 5’ 5’ 3’ 3’ A T T A C G A T COMPLEMENTARY, ANTIPARALLEL POLYNUCLEOTIDE CHAINS OF DNA DOUBLE HELIX the double helix of DNA one nucleotide hydrogen bonds Pu Py Pu Pu Pu Py Py Py Py = pyrimidines Pu = purines
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
BIO 1140 TOPIC 15 SLIDE 4 REPLICATION IS SEMICONSERVATIVE OLD POLYNUCLEOTIDES OLD & NEW POLYNUCLEOTIDES EACH OLD STRAND IS PAIRED WITH ONE NEWLY SYNTHESISED STRAND 5’ 5’ 3’ 3’ 5’ 3’ 3’ 5’ BIO 1140 TOPIC 15 SLIDE 5 SEMICONSERVATIVE NATURE OF REPLICATION INITIAL DNA REPLICATING DNA REPLICATED DNA EACH NEW STRAND HAS ONE OLD POLYNUCLEOTIDE AND ONE NEW POLYNUCLEOTIDE 5’ 5’ 5’ 5’ 5’ 5’ 5’ 5’ 5’ 5’ BIO 1140 TOPIC 15 SLIDE 6 A REPLICON ¾ origin of replication ¾ replication bubble ¾ replication forks 5’ 5’ 3’ 3’ ONE REPLICON: that portion of the chromosome served by one replication origin (50 Kb to 300 Kb long in eukaryotes) [only one in prokaryotes; many in eukaryotes] Note: Kb = kilo base pairs = 1000 base pairs)
Background image of page 2
BIO 1140 TOPIC 15 SLIDE 7 ORIGIN OF BIDIRECTIONAL REPLICATION replication bubble replication forks 5’ 5’ 3’ 3’ leading leading lagging lagging LOOKS SIMPLE: BUT TWO PROBLEMS 3’ 5’ 5’ 3’ Origin of Bidirectional replication: specific DNA sequence rich in AT pairs BIO 1140 TOPIC 15 SLIDE 8 PROBLEMS FOR REPLICATION ¾ DNA polymerase cannot
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 8

15 Replication - BIO 1140 TOPIC 15 SLIDE 1 TOPIC 15...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online