week 4 - 5 - anno

week 4 - 5 - anno - Week 4 July 16, 2010 Test Yourself Now...

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Week 4 July 16, 2010 Test Yourself Now Provide a complete curved-arrow mechanism for the following reaction: 1. LiAlH 4 2. H + wkup 3. H 2 SO 4 O O O 53
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Week 4 July 16, 2010 Reduction of Amides and Nitriles with LiAlH 4 Draw complete curved-arrow mechanisms for the following reactions: 1. LiAlH 4 2. H + workup O N R H N R H Me C N 1. LiAlH 4 2. H + workup Me NH 2 Reading : Section 21.8 54
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Week 4 July 16, 2010 Other Mechanisms of Ester Formation / Hydrolysis Draw a complete curved-arrow mechanism for the following reaction: OH O CH 2 N 2 OCH 3 O Here are some other reactions; identify the type of mechanism. You should do the curved-arrow mechanisms on your own! H + O O OH O + Br + H OH O H O O OH O OCH 3 O K 2 CO 3 CH 3 I OCH 3 O NaCN OH O H 2 O + Me C N Reading : Section 20.8 55
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Week 4 July 16, 2010 The Grid of Carbonyl Love Revisited R H OH R' O Cl OR' NHR' reactant product N R'' RO' RO'' OR'' Carbonyl Review: Fill in the steps required for each transformation X 56
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Week 4 July 16, 2010 Zooming In on the Grid of Carbonyl Love 1. Anything but an amide can be reduced to form a primary alcohol . 2. Acid chlorides can be turned into ketones , and reduced to form secondary alcohols 3. Esters reduced to form aldehydes 4. can be turned into R H OH R R' OH R H O R R' O R OH O R Cl O R OR' O R NHR' O reactant product 57
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Week 4 July 16, 2010
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week 4 - 5 - anno - Week 4 July 16, 2010 Test Yourself Now...

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