ch.7.2 - Ch 7. The Nervous System Synaptic Transmission;...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Ch 7. The Nervous System Synaptic Transmission; Drug Addictions 9/24/08 I. Sequence of chemical transmission Sequence, Summation and Integration II. Transmitters and Receptors Acetylcholine, Amines (dopamine, noradrenalin, serotonin), Amino Acids (glutamate, glycine, GABA), Polypeptides (endorphins, substance P), ATP III. Additive Drugs Cocaine, Morphine/heroin, Nicotine, Marijuana, Addiction, Tolerance, Dependence eurotoxins IV. Neurotoxins Tetrodotoxin (TTX), Conopeptides, alpha-Latrotoxin, Botulinum toxin, alpha- bungarotoxin, curare, nerve gas (Sarin)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ynapses separate one neuron from another. Synapses separate one neuron from another. • Neurons physically do not touch one another. synapse is a gap that separates neurons A synapse is a gap that separates neurons. • Neurotransmitters released from the terminal bulb enter into the synapse and traverse the space (called the synaptic eft) by simple diffusion cleft) by simple diffusion. • Neurotransmitters leave the presynaptic neuron and diffuse toward the postsynaptic neuron, where they settle on receptors and initiate a reaction. • Neurotransmitters are chemicals that carry an impulse across a synaptic cleft. • Currently, there are 45 neurotransmitters identified and studied. 7-32
Background image of page 2
7-34
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A chemical synapse From The Neuron by I Levitan And L. K. Kaczmarek
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Cholinergic Synapses cetyl oA + Choline Acetyl-CoA + Choline acetylcholine (Ach) inside the synaptic vesicle •Vesicle exocytosis Ch released to the ACh released to the synaptic cleft ACh binds to AChR •ACh is broken down by acetylcholinesterase (AChE) into acetate and choline, which can be taken up the nerve terminal
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ynaptic Transmission Synaptic Transmission Animation for Synaptic Transmission
Background image of page 8
•Sequence of chemical synaptic transmission P reaches nerve terminal crease in permeability to Ca 2+ ocytosis of AP reaches nerve terminal increase in permeability to Ca exocytosis of synaptic vesicles transmitter molecules (e.g. acetylcholine) diffuse across the synaptic cleft transmitter molecules bind to receptors (e.g. acetylcholine receptors) on the postsynaptic membrane increase in permeability to certain ions changes in the postsynaptic membrane potential. If Permeability to Na + is increased Na + influx is enhanced excitatory postsynaptic otential, or EPSP. potential, or EPSP. If Permeability to Cl - is increased Cl - influx is enhanced inhibitory postsynaptic potential, or IPSP. If Permeability to K + is increased ?
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 28

ch.7.2 - Ch 7. The Nervous System Synaptic Transmission;...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online