Medchem - Diverse Disciplines in Chemistry Medicinal...

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Unformatted text preview: Diverse Disciplines in Chemistry Medicinal Chemistry in the Practice of Pharmacy Robin M. Zavod, PhD First: Who is Sitting Next to You? Dust off the Rust! Rev up the Brain Cells! Get the pie-hole working again! ICE BREAKER! Work with a group of 3-4 people to identify as many Wacky Wordies as you can! Second: Whats the Plan Tonight? Careers in Chemistry Introduction : What is Pharmacy? What is Medicinal Chemistry? Examples : How is Medicinal Chemistry used in the Practice of Pharmacy? Histamine (receptors) Cyclo-oxygenase (enzymes) What is Pharmacy? Past : Dispense Medications Pharmacist isnt involved with patient education Present : Providers of Pharmaceutical Care Dispensing role de-emphasized Pharmacists are drug information spets Future : Individualized Medicine Genetic information directs medication selection What is Medicinal Chemistry? Drug Mechanism of Action Structure Activity Relationships Drug structure predicts biological activity ADME: Absorption, Distribution, Metabolism, Excretion Tweaking functional groups and formulation Interactions: Biological Target for Drug Action Optimization of drug potency Melding the Two Disciplines If Pharmacists are the drug information spets, what kind of information do they need to know? If Medicinal Chemists are the creators of new drug entities, what kind of information do they need to know? Patient Case #1 E.M., a 43 year old mother of two teenage boys, walks into the pharmacy and says "Getting my two boys off to school this fall will be a challenge. It is more than my head can take at that time of the morning, not to mention my stomach! I cant believe how bad the allergy season has already been. Allergies: Sequence of Events Allergens elicit release of histamine from mast cells Histamine receptors are activated Physiological responses are generated Hives/Rash Runny nose/itchy eyes Wheezing What does it take to stop this process? Indigestion: Sequence of Events Release of histamine into GI tract Overeating, excess consumption of alcohol Stress; Some medications Histamine receptors are activated Physiological response is generated Increased gastric acid production Irritation/ulceration of mucosal lining of the stomach What does it take to stop this process? Are all Histamine Receptors the Same?...
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Medchem - Diverse Disciplines in Chemistry Medicinal...

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