HW1 familiar with major databases

HW1 familiar with major databases - Lai Mei Kwan Michele...

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Lai Mei Kwan Michele BSc(Bioinformatics) II UID: 2008078522 BIOC2808 Assignment 1 BIOC 2808 HW1 familiar with major databases Due 17 Sept., 2009 11:59pm Foxm1 is a gene involves in cell cycle and development. Your professor has been working on this gene for many years and he wants you to find more about this gene. (1pct/question) Go to http://www.ncbi.nlm.nih.gov/sites/gquery , search “FoxM1”, and answer following questions: 1. From OMIM search, what diseases are associated with FoxM1? Depletion of FoxM1 will lead to pleiotropic G2/M defects, including chromosome misalignment, spindle checkpoint dysfunction and defects in cytokinesis. Overexpression of FoxM1 will cause increased entry into mitosis. Hutchinson-Gilford progeria syndrome http://www.ncbi.nlm.gov/entrez/dispomim.cgi?id=602341 2. From 3D domain search, is the protein’s 3D structure solved? Yes. 3. From SNP search, how many SNPs are in this gene in human? 247 SNPs.
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HW1 familiar with major databases - Lai Mei Kwan Michele...

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