lect 07 promoter prediction

lect 07 promoter prediction - Bioc 2808 Lecture 7 Promoter...

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Click to edit Master subtitle style 7/29/10 Bioc 2808 Lecture 7 Promoter prediction Instructor Dr. Junwen Wang
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7/29/10 Transcriptional Regulation TF-DNA Interaction s and Modules Transcriptio n Start Site
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7/29/10 Obj10 Core Promoter : Minimal DNA sequence required for the assembly of the Pre-initiation complex (~100 bps flanking the TSS) Goal : Determine sequence properties responsible for precise Pol-II localiazation
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7/29/10 Today’s topics – three papers Michael Zhang’s paper on CpG island based method Our paper on k-mer propensity based method Our paper on consensus predictor
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7/29/10 1990 1995 2000 2006 TATA PromoterScan Promoter1.0 Autogene PromFind TSSG Calverie NNPP CorePromoter PromoterInspector Hannenhalli FirstEF Dragon PSPA CpG island line
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7/29/10 Long range sequence Characteristics(10kb ) Short genomic Sub regional signal, eg. CpG island(0.5~2kb) Specific cis elements (eg. TATA) Categories of DNA sequence “signals” used in promoter prediction TSS
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7/29/10
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7/29/10 CpG score and promoter
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lect 07 promoter prediction - Bioc 2808 Lecture 7 Promoter...

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