lect 09 Z-score and RoC

# Lect 09 Z-score and - Bioc 2808 Lecture 9 Z-score and RoC Instructor Click to edit Master subtitle style Dr Junwen Wang Basic statistics Z-score

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Click to edit Master subtitle style 7/29/10 Bioc 2808 Lecture 9 Z-score and RoC Instructor Dr. Junwen Wang

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7/29/10 Basic statistics
7/29/10 Z-score Z-score measures the folds of σ a value deviates from its mean. The Z- score is defined as: where: x is a raw score to be standardized. μ is the mean of the population. σ is the standard deviation of

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7/29/10 Binomial distribution Roll a standard die ten times and count the number of sixes. The probability of getting exactly k successes in n trials is given by the probability mass function: The expected value is:
7/29/10 Exercise 1. measuring highly conserved motif When we randomly sample 10000 6- mer from the human genome, we found that about 20% of them have human-mouse conservation (sequence identity) >=80%. We found about 500 AACTTT in the human promoter region, about 200 have sequence identify >=80% What is the Z-score of conservation

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7/29/10 Exercise 2. measuring position specific motif We define human promoter region as
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## This note was uploaded on 07/29/2010 for the course BIOC BIOC2808 taught by Professor Dr.jjwang during the Fall '09 term at HKU.

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Lect 09 Z-score and - Bioc 2808 Lecture 9 Z-score and RoC Instructor Click to edit Master subtitle style Dr Junwen Wang Basic statistics Z-score

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